From the Research
Apixaban for Cerebral Vein Thrombosis
- Apixaban is used for the treatment of cerebral vein thrombosis, as evidenced by several studies 1, 2, 3.
- A case series of patients with cerebral venous thrombosis treated with apixaban showed recanalization in all patients without major side effects 1.
- Another study found that apixaban may be a safe and effective therapy for cerebral venous sinus thrombosis, with a recanalization rate of 74% and no recurrent cerebral venous thrombosis or intracranial hemorrhage 2.
- A case series of three patients with cerebral venous thrombosis treated with apixaban showed resolution of the thrombus and recanalization without bleeding complications 3.
Dosage and Efficacy
- The dosage of apixaban used in these studies varied, with some patients receiving 10 mg twice daily for the first 5-7 days, followed by 5 mg twice daily 1.
- The efficacy of apixaban in treating cerebral vein thrombosis was demonstrated by the achievement of complete or partial recanalization in most patients 1, 2.
- The safety of apixaban was also demonstrated, with few adverse events reported, such as anemia or bleeding complications 1, 2, 3.
Comparison with Other Anticoagulants
- Apixaban has been compared to other anticoagulants, such as warfarin, in the treatment of atrial fibrillation, and has been shown to be safe and effective 4.
- However, the use of apixaban in cerebral vein thrombosis is not as well established as its use in atrial fibrillation, and more studies are needed to confirm its efficacy and safety in this population 1, 2, 3.