From the FDA Drug Label
The median time to alleviation of signs and symptoms in influenza-infected subjects was comparable in the XOFLUZA and oseltamivir arms.
The comparison between Xofluza (Baloxavir) and Tamiflu (Oseltamivir) shows that they have comparable efficacy in treating acute uncomplicated influenza, with similar median times to alleviation of symptoms in clinical trials 1.
From the Research
Introduction to Xofluza (Baloxavir) and Tamiflu (Oseltamivir)
Xofluza (Baloxavir) and Tamiflu (Oseltamivir) are two antiviral medications used to treat influenza.
Mechanism of Action
Xofluza works by inhibiting the cap-dependent endonuclease activity of the PA protein, a subunit of the influenza virus polymerase complex 2, while Tamiflu is a neuraminidase inhibitor.
Comparison of Efficacy
Both Xofluza and Tamiflu have been shown to be effective in treating acute uncomplicated influenza, with similar efficacy in improving influenza symptoms 2, 3.
Key Findings
- Xofluza has been found to reduce influenza viral load more rapidly than Tamiflu 2, 3.
- Xofluza has activity against influenza A and B viruses, including strains resistant to neuraminidase inhibitors 2.
Treatment and Dosage
Xofluza is administered as a single oral dose, with a dosage of 40 mg or 80 mg depending on body weight 4.
Administration
- Xofluza is approved for the treatment of acute uncomplicated influenza in patients 12 years of age and older who have been symptomatic for 48 hours or less 2, 4.
- Tamiflu is typically administered at a dose of 75 mg twice daily for 5 days 5.
Safety and Tolerability
Both Xofluza and Tamiflu have been found to be well-tolerated, with similar adverse event profiles 2, 5, 4.
Common Adverse Reactions
- The most common adverse reactions associated with Xofluza include diarrhea, bronchitis, nausea, nasopharyngitis, and headache 4.
Real-World Effectiveness
A real-world study found that Xofluza was superior to Tamiflu in alleviating influenza symptoms in outpatients with uncomplicated influenza, particularly when treatment was initiated within 12-48 hours of symptom onset 6.
Conclusion
Xofluza (Baloxavir) and Tamiflu (Oseltamivir) are both effective treatments for acute uncomplicated influenza, with Xofluza offering the convenience of a single oral dose and potentially faster reduction in viral load.