From the FDA Drug Label
Facial edema was reported in five patients receiving olmesartan medoxomil. Body as a Whole: Asthenia, angioedema, anaphylactic reactions Skin and Appendages: Alopecia, pruritus, urticaria
Yes, olmesartan can cause swelling, as evidenced by reports of facial edema and angioedema in patients taking the medication 1.
From the Research
Yes, olmesartan can cause leg swelling, as evidenced by studies such as 2, which noted a lower frequency of peripheral edema with olmesartan/amlodipine compared to amlodipine monotherapy, implying that olmesartan itself may contribute to this side effect. This medication, which belongs to the angiotensin II receptor blocker (ARB) class, is commonly used to treat high blood pressure but may cause peripheral edema (swelling in the legs, ankles, and feet) as a side effect. The swelling occurs because olmesartan can cause blood vessels to dilate and increase permeability, allowing fluid to leak into surrounding tissues. This side effect typically appears within the first few weeks of starting the medication or after a dose increase. If you experience leg swelling while taking olmesartan, you should not stop the medication abruptly but instead contact your healthcare provider. They may recommend elevating your legs, reducing salt intake, or possibly adjusting your medication regimen. In some cases, a diuretic might be added to help reduce fluid retention. The swelling is generally dose-dependent, meaning higher doses are more likely to cause this side effect, and it's usually more common in older adults or those with kidney problems, as suggested by studies like 3 and 4. Key points to consider include:
- Olmesartan's efficacy in reducing blood pressure, as shown in studies like 5 and 6
- The importance of monitoring and managing side effects like peripheral edema
- The potential benefits of combining olmesartan with other medications, such as calcium channel blockers, to minimize side effects and maximize blood pressure control, as noted in 2 and 4