What is the effect of hydroxychloroquine (HCQ), ivermectin, and methylene blue on cancer cells?

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Last updated: April 30, 2025View editorial policy

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From the Research

Hydroxychloroquine, ivermectin, and methylene blue are not approved cancer treatments and should not be used for treating cancer. While some laboratory studies have suggested these compounds might affect cancer cells in test tubes, there is insufficient clinical evidence supporting their effectiveness or safety for cancer treatment in humans. Hydroxychloroquine is primarily used for malaria and autoimmune conditions; ivermectin is an antiparasitic medication; and methylene blue is used for methemoglobinemia and as a surgical dye.

Key Points to Consider

  • Cancer requires evidence-based treatments such as chemotherapy, radiation, immunotherapy, or surgery prescribed by oncologists.
  • Using unapproved treatments could delay effective care and potentially cause harm through side effects or drug interactions.
  • If you're concerned about cancer, consult with qualified healthcare providers who can recommend appropriate, proven treatments based on the specific type and stage of cancer.

Relevant Evidence

Studies have shown that these drugs are not effective in treating COVID-19, and there is no substantial evidence to support their use in cancer treatment 1, 2, 3, 4. Although some studies suggest potential anti-viral properties of these drugs, the evidence is limited and inconclusive 4. One study reviewed the potential of repurposing antiparasitic drugs against viruses, including coronaviruses, but found that the level of evidence is low and the efficacy of these drugs remains to be proven 4.

Important Considerations

It's essential to rely on evidence-based treatments for cancer, and patients should be cautious of unapproved treatments that may delay effective care or cause harm. A review of adjunct therapies for pancreatic cancer found that some relatively safe and inexpensive treatment options, such as paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin, have shown success in preclinical models and/or retrospective studies, but more research is needed to confirm their effectiveness 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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