What are the symptoms of pericardial effusion?

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From the Guidelines

Pericardial effusion symptoms include chest pain, shortness of breath, rapid breathing, rapid heart rate, and a feeling of fullness in the chest, which can worsen when lying down and improve when sitting up or leaning forward, as stated in the guidelines by the European Society of Cardiology 1.

Symptoms of Pericardial Effusion

The symptoms of pericardial effusion can vary depending on the size of the effusion and the rate at which it accumulates. Some common symptoms include:

  • Chest pain that worsens when lying down and improves when sitting up or leaning forward
  • Shortness of breath
  • Rapid breathing
  • Rapid heart rate
  • A feeling of fullness in the chest
  • Fatigue
  • Weakness
  • Cough
  • Hiccups
  • Low-grade fever
  • Swelling in the abdomen or legs In severe cases, cardiac tamponade can develop, causing dizziness, fainting, decreased blood pressure, and shock, as noted in the guidelines for the diagnosis and management of pericardial diseases 1.

Severity of Symptoms

The severity of symptoms typically correlates with how quickly the fluid accumulates and how much pressure it exerts on the heart. Patients experiencing these symptoms, particularly chest pain and shortness of breath, should seek immediate medical attention as pericardial effusion can become life-threatening if it progresses to cardiac tamponade. The European Society of Cardiology guidelines emphasize the importance of targeting therapy at the underlying cause of the pericardial effusion, and considering drainage of the effusion when it becomes symptomatic without evidence of inflammation or when empiric anti-inflammatory drugs are not successful 1.

From the Research

Symptoms of Pericardial Effusion

The symptoms of pericardial effusion can vary depending on the size and severity of the effusion, as well as the underlying cause. Some common symptoms include:

  • Chest pain, which can be pleuritic-type and radiate to the left shoulder 2
  • Shortness of breath or dyspnea 3
  • Fatigue
  • Palpitations
  • Fever
  • Pericardial friction rub, which is a scratching sound heard with a stethoscope 3, 2

Diagnostic Criteria

The diagnosis of pericardial effusion is typically made using a combination of clinical findings, laboratory tests, and imaging studies, such as echocardiography. The diagnostic criteria may include:

  • The presence of a pericardial effusion on echocardiography 4, 5, 3
  • Elevated inflammatory markers, such as C-reactive protein 4, 5
  • Clinical signs of tamponade, such as hypotension, jugular venous distension, and pulsus paradoxus 3
  • The presence of underlying conditions, such as cancer, connective tissue disease, or renal failure 5, 3

Treatment Options

The treatment of pericardial effusion depends on the underlying cause and the severity of the effusion. Some treatment options may include:

  • Conservative management, which may be appropriate for asymptomatic patients with small effusions 4
  • Anti-inflammatory medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) 6
  • Pericardiocentesis, which is a procedure to drain the pericardial fluid 5, 3
  • Pericardiectomy, which is a surgical procedure to remove part or all of the pericardium 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Diagnosing pericarditis.

American family physician, 2002

Research

Diagnosis and management of pericardial effusion.

World journal of cardiology, 2011

Research

New Approaches to Management of Pericardial Effusions.

Current cardiology reports, 2021

Research

Triage and management of pericardial effusion.

Journal of cardiovascular medicine (Hagerstown, Md.), 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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