What is the diagnosis for a 6-year-old female presenting with bilateral otalgia (ear pain), bilateral conjunctival discharge described as yellow and purulent, rhinorrhea, cough, headache, fatigue, sore throat, and a red left tympanic membrane, despite treatment with ibuprofen (ibuprofen) and Tylenol (acetaminophen) with cough syrup?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 30, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for 6-year-old Female with Bilateral Ear Pain and Eye Drainage

  • Single most likely diagnosis:
    • Acute otitis media with concurrent conjunctivitis and upper respiratory infection (URI). This diagnosis is most likely due to the combination of bilateral ear pain, yellow and goopy eye drainage, rhinorrhea, cough, headache, fatigue, and sore throat, which are common symptoms of a viral or bacterial infection.
  • Other Likely diagnoses:
    • Viral conjunctivitis with otitis media and URI: The presence of yellow and goopy eye drainage, along with ear pain and URI symptoms, could indicate a viral conjunctivitis.
    • Bacterial conjunctivitis with otitis media and URI: Similar to viral conjunctivitis, but with a higher likelihood of bacterial infection, especially if the eye drainage is thick and purulent.
    • Sinusitis: The symptoms of headache, fatigue, and rhinorrhea could indicate a sinus infection, which may be contributing to the overall clinical picture.
  • Do Not Miss diagnoses:
    • Orbital cellulitis: Although less likely, this diagnosis is critical to consider due to the potential for serious complications, including vision loss and intracranial infection. The presence of eye drainage and redness, along with worsening symptoms, warrants consideration of this diagnosis.
    • Meningitis: Although rare, meningitis can present with similar symptoms, including headache, fatigue, and sore throat. The presence of a red and inflamed left tympanic membrane (TM) and worsening symptoms necessitates consideration of this diagnosis.
  • Rare diagnoses:
    • Kawasaki disease: This rare condition can present with conjunctivitis, otitis media, and URI symptoms, along with other systemic symptoms. Although unlikely, it is essential to consider this diagnosis due to its potential for serious cardiac complications.
    • Juvenile idiopathic arthritis (JIA): This chronic condition can present with conjunctivitis, otitis media, and systemic symptoms, including fever and fatigue. Although rare, JIA is essential to consider in the differential diagnosis to ensure prompt treatment and prevent long-term complications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.