Can I refrigerate my Zepbound (tirzepatide) again after it has been taken out of the fridge?

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Last updated: April 30, 2025View editorial policy

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From the Guidelines

You should put your Zepbound back in the refrigerator when you reach your hotel room, but proper handling during transport is crucial to maintain its effectiveness. Zepbound (tirzepatide) is a temperature-sensitive medication that requires specific storage conditions, similar to insulin, as discussed in a recent study on advance insulin injection technique and education with fitter forward expert recommendations 1. When traveling, it is essential to use a cooler bag with ice packs to maintain the temperature between 36°F to 46°F (2°C to 8°C) for optimal stability.

  • Key considerations for handling Zepbound include:
    • Keeping it refrigerated at 36°F to 46°F (2°C to 8°C) whenever possible
    • Avoiding temperatures above 86°F (30°C) and direct sunlight exposure
    • Not freezing the medication
    • Using a cooler bag with ice packs during transport to maintain the recommended temperature range
  • According to the guidelines for insulin storage, which can be applied to other temperature-sensitive medications like Zepbound, it is crucial to follow the manufacturer's instructions for storage and handling 1.
  • Once you arrive at your hotel, promptly place your Zepbound back in the refrigerator to maintain its effectiveness for weight management.

From the FDA Drug Label

Store ZEPBOUND in a refrigerator at 2°C to 8°C (36°F to 46°F). If needed, each single-dose pen or single-dose vial can be stored unrefrigerated at temperatures not to exceed 30°C (86°F) for up to 21 days. If ZEPBOUND is stored at room temperature, it should not be returned to the refrigerator.

No, you should not put your ZEPBOUND back in the fridge once it has been stored at room temperature, as stated in the drug label 2 and 2.

From the Research

Storage and Handling of Zepbound

  • There are no research papers to assist in answering this question about the storage and handling of Zepbound for weight loss, specifically regarding removing it from the fridge and putting it back in the fridge at a hotel room 3.
  • The available study 3 discusses COVID-19 vaccination and cardiovascular events, which is not relevant to the storage and handling of Zepbound.
  • It is essential to consult the manufacturer's instructions or a healthcare professional for guidance on storing and handling Zepbound.

General Storage and Handling Precautions

  • Typically, medications and supplements should be stored in a cool, dry place, away from direct sunlight and moisture.
  • It is crucial to follow the specific storage instructions provided by the manufacturer to maintain the efficacy and safety of the product.
  • If you have concerns about the storage and handling of Zepbound, it is best to consult the manufacturer's website or contact their customer support for guidance.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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