What are the brand names of metformin extended‑release (Metformin XR)?

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Last updated: March 19, 2026 • View editorial policy

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Metformin Extended-Release Brand Names

Metformin extended-release (XR) is marketed under several brand names, most notably Glucophage XR (the original branded formulation) and Glumetza (a newer extended-release formulation using different delivery technology). 1, 2, 3

Primary Brand Names

  • Glucophage XR: The originator extended-release formulation developed by Merck Healthcare KGaA using GelShield Diffusion System technology, available as once-daily dosing 1, 4

  • Glumetza: A proprietary once-daily extended-release formulation developed by DepoMed using gastric retention (GR) technology, available in 500 mg and 1000 mg tablets 2, 3

Formulation Details

Both formulations provide equivalent bioavailability to immediate-release metformin but with extended absorption profiles that allow once-daily dosing. 2, 4

  • Glucophage XR uses GelShield Diffusion System technology with slower absorption (time to maximum concentration = 7 hours versus 3 hours for immediate-release) 4

  • Glumetza was developed using gastric retention technology and has demonstrated effective glycemic control with once-daily dosing at 1500-2000 mg/day 2

  • The extended-release formulations help mitigate gastrointestinal side effects (bloating, abdominal discomfort, diarrhea) compared to immediate-release metformin 5

Generic Availability

Generic extended-release metformin formulations are available, though Janumet XR (the combination of sitagliptin and metformin XR) has limited generic availability in Western countries. 6

References

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