There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for acetaminophen (PO) do not address this question.
From the Research
Effect of Variable Acetaminophen Dosing on SULT1A1 Enzyme Activity
- The effect of variable acetaminophen dosing on SULT1A1 enzyme activity over 12 days is not directly addressed in the provided studies.
- However, studies have investigated the sulfation of acetaminophen by human cytosolic sulfotransferases, including SULT1A1 1, 2.
- SULT1A1 has been shown to catalyze the sulfation of acetaminophen, with kinetic parameters determined for this reaction 1.
- Polymorphic variants of SULT1A1, including *1, *2, and *3, have been associated with altered enzymatic activity, cellular phenotype, and protein degradation 3.
- The pharmacokinetics of acetaminophen have been studied in various populations, including polymedicated very old patients with rheumatic pain, but these studies do not provide information on the effect of variable dosing on SULT1A1 enzyme activity over 12 days 4.
- Other studies have investigated the bioactivation of other compounds by SULT1A1 and other sulfotransferases, but these studies do not provide relevant information on the effect of variable acetaminophen dosing on SULT1A1 enzyme activity 5.
SULT1A1 Enzyme Activity and Acetaminophen Sulfation
- SULT1A1 is one of the major human cytosolic sulfotransferases responsible for the sulfation of acetaminophen 1, 2.
- The sulfation of acetaminophen by SULT1A1 is an important step in its metabolism, and alterations in SULT1A1 activity may affect the pharmacokinetics and pharmacodynamics of acetaminophen 1, 2.
- However, the provided studies do not investigate the effect of variable acetaminophen dosing on SULT1A1 enzyme activity over 12 days, and therefore do not provide direct evidence to answer this question.