What is the Dulera (mometasone and formoterol) dose comparable to Advair (fluticasone and salmeterol) 100?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Article Review Status
Submitted
Under Review
Approved

Last updated: April 30, 2025 • View editorial policy

From the Research

Dulera 100/5 (100 mcg mometasone/5 mcg formoterol) is generally considered comparable to Advair 100/50 (100 mcg fluticasone/50 mcg salmeterol). Both medications are inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) combinations used to treat asthma, though they contain different specific medications. The typical dosing for Dulera 100/5 is two inhalations twice daily, similar to Advair 100/50's dosing schedule. When switching between these medications, patients should maintain the same dosing frequency (twice daily) but should be aware that the medications may feel different when inhaled due to different delivery devices - Dulera uses a metered-dose inhaler while Advair typically uses a dry powder inhaler (Diskus). Patients should rinse their mouth after using either medication to prevent thrush.

  • The comparable dosing is based on relative potency of the corticosteroid components and the similar effects of the LABA components, though individual responses may vary.
  • Any medication change should be supervised by a healthcare provider who can monitor for effectiveness and side effects during the transition, as supported by studies such as 1 which compared the efficacy and onset of action of mometasone furoate/formoterol and fluticasone propionate/salmeterol combination treatment in subjects with persistent asthma.
  • It's also important to consider the long-term safety of these medications, as shown in studies like 2 which evaluated the long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma.
  • Additionally, network meta-analyses like 3 have compared the efficacy of different long-acting inhaled therapies, including ICS/LABA combinations, for the treatment of COPD, providing further insight into the relative effectiveness of these treatments.

References

Research

Efficacy and onset of action of mometasone furoate/formoterol and fluticasone propionate/salmeterol combination treatment in subjects with persistent asthma.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2011

Research

Long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma.

The Journal of asthma : official journal of the Association for the Care of Asthma, 2010

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.