Brand Name of Azelastine-Fluticasone Combination
The brand name of the azelastine-fluticasone combination nasal spray is Dymista® (also referred to as MP29-02 or MP-AzeFlu in clinical literature). 1, 2, 3
Product Details
Dymista® is manufactured by Meda Pharma GmbH & Co., KG and contains azelastine hydrochloride 137 mcg (equivalent to 125 mcg azelastine base) and fluticasone propionate 50 mcg per spray. 2, 3, 4
The formulation delivers a total daily dose of 548 mcg azelastine hydrochloride and 200 mcg fluticasone propionate when administered as one spray per nostril twice daily. 5
This combination product utilizes an advanced delivery system that distinguishes it from simply using the two commercially available monotherapy products together. 3, 4
Generic Availability
Generic versions of azelastine-fluticasone became available in 2020 after the original manufacturer's patent enforcement ended, leading to increased Medicare utilization and decreased overall spending, though retail prices for generics remain elevated. 6
Generic formulations manufactured in China (referred to as "AzeFlu" in clinical trials) have demonstrated equivalent efficacy and safety to the original Dymista® brand in randomized controlled trials. 1
Clinical Context
The combination product has been shown to be twice as effective as either azelastine or fluticasone propionate monotherapy for nasal and ocular symptom relief in moderate-to-severe seasonal allergic rhinitis, with onset of action within 30 minutes (some studies report as fast as 5 minutes). 2, 7
Dymista® represents the first intranasal therapy to surpass the efficacy of intranasal corticosteroid monotherapy, which had been considered the gold standard for allergic rhinitis treatment. 3, 4