From the Research
The ICD-10 code for an allergic reaction to doxycycline characterized by swelling, hives, and redness is T36.4X5A (Adverse effect of tetracyclines, initial encounter). This code should be used when documenting an allergic reaction to doxycycline, which belongs to the tetracycline class of antibiotics. Additionally, you should include secondary codes to describe the specific manifestations of the allergic reaction: L50.9 for urticaria (hives), R60.9 for unspecified edema (swelling), and L53.9 for erythema (redness) 1. When documenting this in a medical record, it's essential to clearly note that the patient has a doxycycline allergy to ensure this information is added to their allergy list to prevent future exposure. These reactions typically represent a type I hypersensitivity reaction mediated by IgE antibodies, causing mast cell degranulation and the release of histamine and other inflammatory mediators that produce the symptoms of swelling, hives, and redness.
Some key points to consider when managing a patient with a doxycycline allergy include:
- The potential for cross-reactivity with other tetracyclines, such as minocycline and tigecycline 2
- The importance of skin testing and graded challenge procedures to diagnose and manage hypersensitivity reactions 2
- The potential benefits of desensitization procedures for patients who require tetracyclines but have developed hypersensitivity reactions 2
- The need for careful monitoring and management of patients with a history of allergic reactions to doxycycline or other tetracyclines 1.
It's also worth noting that doxycycline has been shown to have anti-allergic properties, and may be useful in the treatment of certain allergic conditions 3, 4. However, this does not negate the importance of careful management and monitoring of patients with a known doxycycline allergy.