What is the most appropriate treatment plan for a 27-year-old man with epiploic appendagitis, presenting with right lower quadrant abdominal pain, focal tenderness, and a normal white blood cell (WBC) count, diagnosed by computed tomography (CT) scan?

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Last updated: April 30, 2025View editorial policy

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From the Research

The most appropriate treatment plan for this 27-year-old man with epiploic appendagitis is nonsteroidal anti-inflammatory medication. Epiploic appendagitis is a self-limiting condition caused by torsion or thrombosis of the epiploic appendages (small fat-filled sacs attached to the colon) [ 1 ]. Despite presenting with symptoms that can mimic appendicitis, including right lower quadrant pain, this condition does not require surgical intervention or antibiotics. The patient's normal white blood cell count (9,800/µL is within normal range) also supports a non-infectious etiology.

Key Points to Consider

  • NSAIDs such as ibuprofen 400-600 mg every 6-8 hours or naproxen 500 mg twice daily for 7-10 days will help manage the inflammation and pain [ 2 ].
  • The patient can be discharged home with instructions to return if symptoms worsen or fail to improve within 1-2 weeks.
  • Most cases resolve completely within 2 weeks with conservative management [ 3 ].
  • Admission for observation is unnecessary given the benign nature of this condition, and surgical consultation would be excessive as this is not a surgical emergency [ 4 ].
  • A systematic review of epiploic appendagitis cases found that most patients were treated conservatively, and surgical treatment was only necessary in a small number of cases [ 3 ].

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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