Pediatric Appendicitis Score (PAS) Criteria
The Pediatric Appendicitis Score consists of 8 clinical and laboratory variables totaling 10 points: cough/percussion/hopping tenderness in the right lower quadrant (2 points), right iliac fossa tenderness (2 points), fever >38°C (1 point), anorexia (1 point), nausea/vomiting (1 point), migration of pain to the right lower quadrant (1 point), leukocytosis >10,000 cells/mm³ (1 point), and polymorphonuclear neutrophilia >7,500 cells/mm³ (1 point). 1
Score Components and Point Assignment
The PAS was specifically designed for children aged 4-15 years and assigns differential weighting based on diagnostic value 1:
Physical Examination Findings (4 points maximum)
- Cough/percussion/hopping tenderness in the right lower quadrant: 2 points — this has the highest diagnostic index (0.96) among all variables 1
- Tenderness over the right iliac fossa: 2 points — diagnostic index of 0.84 1
Clinical Symptoms (3 points maximum)
- Anorexia: 1 point — diagnostic index of 0.88 1
- Pyrexia (fever >38°C): 1 point — diagnostic index of 0.87 1
- Nausea/emesis: 1 point — diagnostic index of 0.86 1
Pain Characteristics (1 point maximum)
- Migration of pain: 1 point — diagnostic index of 0.80 1
Laboratory Values (2 points maximum)
- Leukocytosis (white blood cell count >10,000 cells/mm³): 1 point — diagnostic index of 0.81 1
- Polymorphonuclear neutrophilia (>7,500 cells/mm³): 1 point — diagnostic index of 0.80 1
Score Interpretation and Clinical Application
Use two cut-points rather than a single threshold to optimize diagnostic accuracy 2, 3:
Low-Risk Category (PAS ≤2)
- Discharge home without further investigation — sensitivity of 97.6% and negative predictive value of 97.7% 2
- Only 2.4% of children with appendicitis would be missed using this threshold 2, 3
- This score range captures approximately 73% of children without appendicitis 3
Intermediate-Risk Category (PAS 3-7)
- Proceed with imaging (ultrasound first-line) or observation 2, 3
- This range includes 37% of children with appendicitis and 23% without appendicitis 3
- Further diagnostic workup is essential in this group 2, 3
High-Risk Category (PAS ≥8)
- Proceed directly to appendectomy — specificity of 95.1% and positive predictive value of 85.2% 2
- Using this threshold, the negative appendectomy rate would be 8.8% 2
- This score range identifies 61% of children with appendicitis 3
Important Caveats and Limitations
The PAS has reduced reliability in children under 5 years of age — atypical presentations predominate in this population, making clinical scoring systems less dependable 4. Do not rely exclusively on the PAS for diagnosis in preschool-aged children 4.
The original derivation study showed excellent performance (sensitivity 1.0, specificity 0.92) when administered by pediatric surgeons 1, but validation by emergency physicians in real-world settings demonstrated that using a single cut-point of ≥5 resulted in an unacceptably high false-positive rate of 37.6% 2.
Using the two-threshold approach (≤4 for discharge, ≥8 for surgery) would avoid 41% of imaging investigations while maintaining excellent diagnostic accuracy 2.