Can Lexapro (escitalopram) cause oligomenorrhea or amenorrhea?

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Last updated: February 17, 2025 • View editorial policy

From the FDA Drug Label

Menstrual Disorder 2% 1% The FDA drug label mentions Menstrual Disorder as an adverse reaction, but it does not specifically mention oligomenorrhea or amenorrhea. However, Menstrual Disorder could be related to these conditions. Based on this information, it can be inferred that Lexapro (escitalopram) may be associated with menstrual disorders, but the specific relationship to oligomenorrhea or amenorrhea is not clearly established 1.

From the Research

Effects of Lexapro (Escitalopram) on Menstrual Cycle

  • There is no direct evidence in the provided studies that Lexapro (escitalopram) causes oligomenorrhea or amenorrhea 2, 3, 4, 5, 6.
  • The studies primarily focus on the pharmacoeconomic aspects, efficacy, and mechanism of action of escitalopram, without discussing its effects on the menstrual cycle.
  • None of the studies mention oligomenorrhea or amenorrhea as potential side effects of escitalopram, suggesting that these effects may not be well-documented or widely recognized in the context of escitalopram treatment 2, 3, 4, 5, 6.

Potential Mechanisms and Side Effects

  • Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the brain, which may have indirect effects on various physiological processes, including hormonal regulation 5.
  • However, the provided studies do not explore the potential effects of escitalopram on the hypothalamic-pituitary-gonadal axis or menstrual cycle regulation 2, 3, 4, 5, 6.
  • Further research would be necessary to determine whether escitalopram has any significant effects on menstrual cycle regularity or fertility 2, 3, 4, 5, 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.