From the Guidelines
Amoebic Infection Treatment with Humatin (Paromomycin)
The recommended dosage of Humatin (Paromomycin) for an amoebic infection is 25-30 mg/kg/day, divided into 2-3 doses, as indicated by the treatment guidelines for parasites 1.
- For a typical adult, this translates to approximately 500 mg t.i.d. (three times a day) for 7 days, considering the average weight and the standard dosing regimen.
- The dosage is based on the patient's weight, with a maximum daily dose not exceeding 4 grams, ensuring safety and efficacy in treating the infection.
- It's crucial to follow the prescribed dosage and treatment duration to effectively clear the infection and minimize the risk of recurrence or complications, as supported by the guidelines for managing infectious diseases 1.
From the FDA Drug Label
DOSAGE AND ADMINISTRATION Intestinal amebiasis: Adults and Pediatric Patients: Usual dose—25 to 35 mg/kg body weight daily, administered in three doses with meals, for five to ten days. The dosage of Humatin (Paromomycin) for an amoebic infection is:
- 25 to 35 mg/kg body weight daily,
- administered in three doses with meals,
- for five to ten days 2.
From the Research
Dosage of Humatin (Paromomycin) for Amoebic Infection
The dosage of Humatin (Paromomycin) for an amoebic infection is not explicitly stated in the provided studies. However, the following information can be gathered:
- For the treatment of visceral leishmaniasis, a study 3 used paromomycin sulphate at a dose of 15 mg/kg/day for 28 days or 20 mg/kg/day for 21 days.
- For the treatment of Cryptosporidium serpentis infection in a king cobra, a study 4 used paromomycin at a dose of 360 mg/kg, orally, twice weekly for 6 weeks.
- For the treatment of amoebiasis, a study 5 mentions that treatment with an amebicidal drug such as metronidazole/tinidazole and a luminal cysticidal agent such as paromomycin is indicated, but does not specify the dosage of paromomycin.
Key Points
- The dosage of paromomycin for amoebic infection is not clearly stated in the provided studies.
- Different dosages of paromomycin have been used for the treatment of various infections, including visceral leishmaniasis and Cryptosporidium serpentis infection.
- Further research is needed to determine the effective dosage of paromomycin for the treatment of amoebic infections.