From the Research
Trintellix is not the focus of the provided evidence, however, based on the available information, the question seems to be about oxandrolone, not trintellix. Given the context, it appears there might be confusion in the question posed. The evidence provided relates to oxandrolone, an anabolic steroid used in various medical conditions, including severe burns, HIV-related wasting, and other catabolic disorders.
Oxandrolone Use and Efficacy
- Oxandrolone has been shown to be effective in promoting anabolism in patients with chronic wasting conditions and in the prevention and treatment of frailty associated with loss of muscle tissue in aging (sarcopenia) 1.
- It is particularly noted for its use in severe thermal injury, where it enhances lean body mass accretion, restores body weight, and accelerates wound healing 2, 3.
- The most recent and highest quality study on oxandrolone, a 2020 systematic review and meta-analysis, indicates that oxandrolone does not affect mortality rates or progressive liver dysfunction but significantly decreases length of hospital stay, increases weight regain, bone mineral density, and percent lean body mass, and decreases wound healing time for donor graft sites 4.
Safety and Side Effects
- Oxandrolone is generally well-tolerated, with common side effects including transient elevations in transaminase levels and reductions in high-density lipoprotein cholesterol level 1.
- Unlike other anabolic steroids, oxandrolone has a lower risk of serious hepatotoxic effects due to its novel chemical configuration that confers resistance to liver metabolism 1.
- Monitoring of liver enzymes is recommended when using oxandrolone, although evidence suggests it does not increase the risk of progressive or transient liver injury 4.
Recommendation
Based on the most recent and highest quality evidence, oxandrolone is a beneficial adjunct in the treatment of severe burns and other catabolic conditions, offering improvements in lean body mass, wound healing, and hospital stay duration without significant increases in liver injury risk 4. It's crucial to follow the recommended dosage and monitor patients for potential side effects, ensuring the benefits of oxandrolone therapy are maximized while minimizing risks.