From the Guidelines
Gardasil 9 Prescription
The recommended prescription for Gardasil 9 vaccine is to administer 0.5 mL of Gardasil 9 (Human Papillomavirus 9-valent Vaccine, Recombinant) intramuscularly.
- For individuals 9 through 14 years of age, a 2-dose series is recommended, with the second dose administered 6 to 12 months after the first dose 1.
- For individuals 15 years of age and older, a 3-dose series is recommended, with the second dose administered 2 months after the first dose, and the third dose administered 6 months after the first dose 1. The dose should be administered in the deltoid muscle or the anterolateral thigh in infants under 1 year of age. Key points to consider:
- The vaccine is contraindicated in individuals with a yeast allergy 1.
- The most common side effect is headache, which occurs in up to one half of patients 1.
- There is a risk of syncope, which has been reported following other intramuscular vaccinations, and patients should be observed for 15 minutes following administration 1.
From the FDA Drug Label
DOSAGE AND ADMINISTRATION For intramuscular administration only. (2) Each dose of GARDASIL 9 is 0. 5-mL Administer GARDASIL 9 as follows: (2.1) AgeRegimenSchedule * If the second dose is administered earlier than 5 months after the first dose, administer a third dose at least 4 months after the second dose. (14.2 and 14.7) 9 through 14 years2-dose0, 6 to 12 months* 3-dose0, 2,6 months 15 through 45 years3-dose0, 2,6 months
The prescription for Gardasil 9 is:
- For individuals 9 through 14 years: 2-dose regimen at 0 and 6 to 12 months, or 3-dose regimen at 0,2, and 6 months.
- For individuals 15 through 45 years: 3-dose regimen at 0,2, and 6 months. Each dose is 0.5-mL and administered intramuscularly 2.
From the Research
Gardasil 9 (Human Papillomavirus 9-valent Vaccine) Prescription
- The prescription for Gardasil 9 is not explicitly stated in the provided studies, but the administration schedule for the 9-valent human papillomavirus vaccine can be found in the study 3.
- According to the study 3, the 9-valent human papillomavirus vaccine is administered intramuscularly in a 0.5 mL dose at day 1, months 2 and 6.
- The study 4 also mentions the administration schedule for the 9-valent human papillomavirus vaccine, which is 2 doses (months 0 and 6 or months 0 and 12) or 3 doses (months 0,2, and 6).
- It is worth noting that the studies 5 and 6 discuss the quadrivalent human papillomavirus vaccine, which has a different administration schedule, with 3 doses of 0.5 mL given intramuscularly at 0,2, and 6 months 5, 6.
Administration Schedule
- The administration schedule for Gardasil 9 may vary depending on the population being vaccinated, with studies suggesting 2-dose regimens (months 0,6 or 0,12) or 3-dose regimens (months 0,2,6) 3, 4.
- The study 4 found that antibody responses generated by 2 doses administered 6 to 12 months apart may be sufficient to induce high-level protective efficacy through at least 2 years after the second dose.