From the Guidelines
First-Line Antibiotic Dosing for UTI
The first-line antibiotic dosing for a 10-year-old, 46.2 kg patient with a Urinary Tract Infection (UTI) is amoxicillin-clavulanate at 20–40 mg/kg per day in 3 doses or cephalosporin such as cefixime at 8 mg/kg per day in 1 dose 1.
- The recommended dosing for amoxicillin-clavulanate would be approximately 924-1848 mg per day, divided into 3 doses of around 308-616 mg each.
- For cefixime, the dosing would be approximately 369 mg per day, given in 1 dose.
- It is essential to consider local patterns of susceptibility of coliforms to antimicrobial agents when selecting an antibiotic, as there is substantial geographic variability 1.
- The total course of therapy should be 7 to 14 days, with a minimum duration of 7 days to ensure effective treatment of the UTI 1.
From the FDA Drug Label
Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. The following table is a guideline for the attainment of this dosage: Children 2 months of age and older: Weight Dose – every 12 hours lb kg Tablets 22-44 10-20 1 66-88 30-40 2 or 1 DS tablet 88-110 40-50 2 or 1 DS tablet
For a 10-year-old patient weighing 46.2 kg with a Urinary Tract Infection (UTI), the first-line antibiotic dosing is:
- 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days.
- Based on the weight, the dose would be approximately 1848 mg sulfamethoxazole and 369.6 mg trimethoprim per 24 hours.
- This would translate to approximately 924 mg sulfamethoxazole and 184.8 mg trimethoprim every 12 hours.
- According to the dosage table, the patient would likely require 2 or 1 DS tablet every 12 hours 2.