From the Guidelines
Oral Prednisone Dosing for a 5-Day Burst
The recommended oral prednisone dosing for a 5-day burst in an 82 kg female is 40-60 mg per day 1.
- A typical regimen consists of 50 mg of prednisone tablets administered orally once daily for 5 consecutive days.
- The exact dose may vary depending on the specific clinical indication and individual patient factors, but 50 mg daily for 5 days is a commonly used regimen 1.
- It is essential to note that the dosing guidelines provided are for outpatient burst therapy, and the dose should not exceed 60 mg/day in divided doses until the peak expiratory flow (PEF) reaches 70% of predicted or personal best 1.
- For adults, the guidelines suggest using 40-60 mg in single or 2 divided doses for a total of 5-10 days 1.
From the Research
Oral Prednisone Dosing
- The dosing for a 5-day burst of oral prednisone is not explicitly stated for an 82 kg female in the provided studies.
- However, study 2 mentions that adult emergency department patients with acute exacerbations of asthma received 50 mg of daily oral prednisone for 5 days.
- Study 3 reports that MS patients were treated with 1,250 mg of oral prednisone daily for acute relapses, but this is a much higher dose and not directly applicable to the question.
- Study 4 discusses a 5-day course of oral prednisolone (1 mg/kg) for children with asthma exacerbations, which could be used as a reference point for calculating the dose for an 82 kg female.
- Using the dosage from study 4 as a reference, the calculated dose for an 82 kg female would be approximately 82 mg of oral prednisone per day for 5 days.
- It is essential to note that the ideal dose may vary depending on the specific condition being treated and individual patient factors, and these studies do not provide a direct answer for the oral prednisone dosing for a 5-day burst in an 82 kg female 2, 3, 4, 5, 6.