What is the recommended adult dose of Mylanta (aluminum hydroxide, magnesium hydroxide, and simethicone) in milligrams?

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Last updated: March 25, 2026 • View editorial policy

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Mylanta Adult Dosing

For adults and children 12 years and older, the recommended dose of Mylanta is 10–20 mL (equivalent to 800–1,600 mg aluminum hydroxide, 800–1,600 mg magnesium hydroxide, and 80–160 mg simethicone per dose) taken between meals, at bedtime, or as directed, with a maximum of 60 mL (six doses) in any 24-hour period. 1

Dosing Details

  • Standard dose range: 10–20 mL per dose 1
  • Active ingredients per 10 mL: 1
    • Aluminum hydroxide: 800 mg
    • Magnesium hydroxide: 800 mg
    • Simethicone: 80 mg
  • Maximum daily dose: 60 mL (six doses) in 24 hours 1
  • Duration limit: Do not use maximum dosage for more than 2 weeks 1
  • Administration: Shake well before use; measure with provided dosing cup 1

Important Clinical Considerations

Drug Interactions

  • Azithromycin: Administer Mylanta at least 1 hour before or 2 hours after azithromycin to prevent reduced antibiotic bioavailability 2
  • General absorption concerns: Aluminum-magnesium antacids can reduce absorption of multiple medications; timing separation is critical 3, 4

Special Populations

Chronic Kidney Disease (CKD): 2

  • Aluminum hydroxide may be used as a phosphate binder but should be limited to 1–2 days maximum to avoid aluminum toxicity
  • Prolonged aluminum exposure in CKD causes bone disease and neurotoxicity 5, 2
  • Magnesium-containing products require caution due to risk of magnesium accumulation with impaired renal clearance 2

Pediatric patients (under 12 years): Ask a doctor before use 1

Therapeutic Limitations

  • Rapid onset but short duration: Mylanta acts quickly but provides shorter symptom relief than H₂-receptor antagonists or proton-pump inhibitors 2
  • Limited GERD efficacy: Antacids provide limited symptom relief for gastroesophageal reflux disease and are relatively benign but not first-line therapy 2

Safety Profile

  • Minimal systemic absorption of aluminum has been demonstrated in healthy women under fed conditions 6
  • Magnesium is detected only at normal physiologic concentrations after antacid administration 6

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.