What is the cause of severe back pain and constipation in a patient taking cyclobenzaprine (Flexeril) for back spasms, with ineffective relief from senna (Senokot) and miralax (polyethylene glycol), and a history of leg cramps and possible dehydration?

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Differential Diagnosis

  • Single most likely diagnosis
    • Constipation due to medication side effects (e.g., cyclobenzaprine) and dehydration: The patient's recent use of cyclobenzaprine, a muscle relaxer known to cause constipation, combined with inadequate hydration and a disrupted routine, makes this a likely cause of their constipation.
  • Other Likely diagnoses
    • Constipation due to decreased physical activity and travel: The patient's travel schedule and potential decrease in physical activity may have contributed to their constipation.
    • Functional constipation: The patient's symptoms, including infrequent bowel movements and difficulty passing stools, are consistent with functional constipation.
    • Back pain-related constipation: The patient's severe back pain may be causing them to avoid physical activity, leading to constipation.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Cauda equina syndrome: Although the patient denies new onset loss of bowel or bladder control and numbness or tingling in the perineal region, cauda equina syndrome is a medical emergency that requires prompt attention. The patient's severe back pain and constipation warrant consideration of this diagnosis.
    • Spinal cord compression: Similar to cauda equina syndrome, spinal cord compression is a serious condition that can cause constipation, back pain, and neurological symptoms.
    • Intestinal obstruction: Although less likely, intestinal obstruction can cause severe constipation, abdominal pain, and vomiting.
  • Rare diagnoses
    • Neurogenic bowel dysfunction: This condition, which can cause constipation, is often associated with neurological disorders such as multiple sclerosis or spinal cord injuries.
    • Endocrine disorders (e.g., hypothyroidism): Certain endocrine disorders can cause constipation, although this is less likely given the patient's presentation.
    • Colonic inertia: A rare condition characterized by a decrease in colonic motility, leading to severe constipation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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