What is the cause of a 3-year history of erythematous (red and inflamed) patches on the arms, with occasional spread, peeling, and dryness around the eyes and ears, unresponsive to topical creams prescribed by a dermatologist (skin specialist)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 1, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Skin Changes

The patient presents with patches of bumps on her skin, primarily on her arms, which become red and inflamed, along with peeling, dry, white skin on one ear and similar dryness around her eyes. Considering her symptoms and the lack of response to previous treatments, the following differential diagnoses are proposed:

  • Single most likely diagnosis
    • Seborrheic Dermatitis: This condition is characterized by a red, itchy, and flaky rash, often affecting areas rich in sebaceous glands like the face, ears, and scalp. The patient's description of patches becoming red and inflamed, along with dryness and flaking around the eyes and on the ear, aligns with seborrheic dermatitis. Although she denies significant itching, this symptom can vary among patients.
  • Other Likely diagnoses
    • Psoriasis: Given the description of patches of bumps that become red and inflamed, psoriasis is a plausible diagnosis. The presence of dry, white skin on one ear and similar dryness around the eyes could also be indicative of psoriatic plaques.
    • Eczema (Atopic Dermatitis): Although the patient denies significant itching, eczema could still be considered, especially given the appearance of patches on the arms and the fact that these patches can sometimes spread. Eczema can present with a wide range of symptoms, including dryness and inflammation.
    • Keratosis Pilaris: This condition causes small, rough patches on the skin, often on the arms, and can be associated with dry skin. The patient's mention of patches of bumps could align with keratosis pilaris, especially if the bumps are small and rough to the touch.
  • Do Not Miss
    • Cutaneous T-cell Lymphoma (Mycosis Fungoides): Although less common, this condition can present with skin patches, plaques, or lesions that can be mistaken for more benign dermatological conditions. It's crucial to consider this diagnosis due to its potential severity and the need for early intervention.
    • Sarcoidosis: This systemic disease can cause skin lesions, among other symptoms, and should be considered, especially if the patient has other systemic symptoms or if the skin lesions are atypical.
  • Rare diagnoses
    • Pityriasis Rubra Pilaris: A rare skin disorder characterized by constant scaling, redness, and thickening of the skin, which could potentially explain the patient's symptoms, especially the dry, white skin and the patches of bumps.
    • Darier Disease: A rare genetic disorder that affects the skin, causing signs such as greasy, crusted patches on the skin, which might resemble the patient's symptoms, although it typically involves more areas and has a distinct appearance.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.