What are the brand names for dexmethylphenidate?

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Last updated: March 25, 2026 • View editorial policy

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Brand Names for Dexmethylphenidate

Dexmethylphenidate is marketed under the brand name Focalin (immediate-release) and Focalin XR (extended-release). 1, 2, 3

Available Formulations

Immediate-Release (Focalin)

  • Focalin is the brand name for immediate-release dexmethylphenidate hydrochloride 3
  • Available as D-shaped tablets in 2.5 mg, 5 mg, and 10 mg doses 3
  • Requires twice-daily dosing 4

Extended-Release (Focalin XR)

  • Focalin XR is the brand name for extended-release dexmethylphenidate hydrochloride 1, 2
  • Available as extended-release capsules in 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg, 35 mg, and 40 mg strengths 1
  • Utilizes a bimodal release profile with immediate-release and delayed-release beads, allowing once-daily administration 1, 2
  • Can be opened and sprinkled on applesauce for patients unable to swallow capsules whole 2

Newer Combination Product

Serdexmethylphenidate/Dexmethylphenidate (Azstarys)

  • Azstarys is a newer formulation combining serdexmethylphenidate (a prodrug of dexmethylphenidate) with immediate-release dexmethylphenidate 5, 6
  • Approved for patients aged ≥6 years with ADHD 6
  • Provides once-daily dosing with extended duration of action 5, 7
  • The prodrug design potentially reduces abuse potential compared to standard dexmethylphenidate 8

Key Clinical Distinctions

Dexmethylphenidate represents the pharmacologically active d-threo-enantiomer of racemic methylphenidate (Ritalin), allowing for lower dosing compared to mixed-isomer formulations. 1, 3

  • Dexmethylphenidate provides effective ADHD management at approximately half the dose of racemic methylphenidate 3
  • The extended-release formulation (Focalin XR) mimics two doses of immediate-release dexmethylphenidate given 4 hours apart 2
  • Duration of effect extends up to 12 hours post-dose with extended-release formulations 2, 9

References

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