From the Guidelines
No, a repeat of the entire HPV vaccine series is not necessary if you missed the third dose, and you should simply get the missed third dose as soon as possible. The HPV vaccine series does not need to be restarted if it is interrupted, according to the recommendations of the Advisory Committee on Immunization Practices (ACIP) 1. If the series is interrupted after the first dose, the second dose should be administered as soon as possible, and the second and third doses should be separated by an interval of at least 12 weeks. However, if only the third dose is delayed, it should be administered as soon as possible, without the need to restart the series. Some key points to consider when dealing with an interrupted HPV vaccine series include:
- The immune system forms memory cells after the initial doses, so even with a delay, your body will recognize the vaccine and mount an appropriate immune response when you receive the final dose.
- Public health authorities recommend completing the series rather than restarting it, as the previous doses still provide partial protection and prime your immune system for the final dose.
- The HPV vaccine series consists of either two or three doses depending on the age when the series was started, and the timing of the doses can be adjusted based on the individual's circumstances. It's essential to consult with a healthcare provider to determine the best course of action for completing the HPV vaccine series, as they can assess individual circumstances and provide personalized guidance 1.
From the Research
HPV Vaccine Series Completion
- The HPV vaccine is a three-dose series, and completion of the series is crucial for optimal protection against HPV-related diseases 2.
- Studies have shown that incomplete HPV vaccination rates are high, especially among individuals over 26 years old 3.
- Factors such as age, neighborhood, and provider awareness can affect HPV vaccine series completion rates 3, 4.
Missed Opportunities for Vaccination
- Missed opportunities for vaccination can occur when individuals attend clinic visits but do not receive the next dose of the vaccine 4.
- Provider awareness of vaccine updates and patient interventions can improve vaccine series completion rates 4.
Delayed Dosing Intervals
- Delayed dosing intervals for the quadrivalent HPV vaccine do not reduce antibody avidity, and may even result in higher antibody titers 5.
- Longer intervals between doses can result in higher antibody avidity, providing further evidence that delayed dosing does not hinder the immune response 5.