Should I continue my zinc supplement when receiving botulinum toxin (Botox) injections to enhance its efficacy?

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Last updated: March 26, 2026 • View editorial policy

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Continue taking your zinc supplement at the usual dose (typically 15–30 mg elemental zinc per day) when you receive botulinum toxin (Botox) injections; there is no evidence that zinc improves the efficacy of Botox, nor is there any known interaction that requires stopping or adjusting the supplement. Do not increase the zinc dose solely to try to enhance Botox results, as higher doses can cause gastrointestinal upset and may lead to copper deficiency. If you are taking very high amounts of zinc (more than 50 mg elemental zinc daily) or have any kidney disease, gastrointestinal disorders, or are pregnant, discuss the dose with your clinician. Otherwise, maintain your regular zinc regimen and follow your provider’s schedule for Botox injections. No additional interventions are needed.

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