What is the risk of Venous Thromboembolism (VTE) with Ethinylestradiol (EE)/Levonorgestrel (LN) compared to Drospirenone (DRSP)?

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From the Guidelines

Ethinylestradiol/levonorgestrel-containing oral contraceptives are recommended over drospirenone for patients concerned about venous thromboembolism (VTE) risk due to their lower VTE risk profile. The most recent and highest quality study 1 supports this recommendation, indicating that levonorgestrel-containing pills carry approximately half the VTE risk of those containing drospirenone.

Key Points to Consider

  • The absolute risk difference is small but significant, with approximately 6-7 cases per 10,000 women-years for levonorgestrel combinations versus 9-12 cases per 10,000 women-years for drospirenone combinations 1.
  • Drospirenone's antimineralocorticoid and antiandrogenic properties may increase thrombogenic potential, contributing to the higher VTE risk 1.
  • The estrogen component (ethinylestradiol) contributes to VTE risk in both formulations, but the progestin type significantly modifies this risk 1.
  • When prescribing, individual patient factors such as personal or family history of thrombosis, presence of other risk factors, and patient preferences regarding other contraceptive benefits should be considered 1.

Patient-Specific Considerations

  • Patients with a history of thrombosis or at high risk of VTE may benefit from levonorgestrel-containing pills due to their lower VTE risk profile.
  • Patients who prioritize acne control or PMDD management may still consider drospirenone-containing pills, despite the slightly higher VTE risk, as they may offer advantages in these areas 1.
  • A comprehensive medical history and measurement of blood pressure are essential before prescribing COCs, and patient eligibility self-screening tools can help expand COC access 1.

From the FDA Drug Label

COCs containing DRSP may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins. Based on presently available information on DRSP-containing COCs with 0.03 mg ethinyl estradiol (that is, Yasmin), DRSP-containing COCs may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing the progestin levonorgestrel or some other progestins.

The risk of Venous Thromboembolism (VTE) is higher with Drospirenone compared to Levonorgestrel.

  • Drospirenone may be associated with a higher risk of VTE than COCs containing Levonorgestrel or some other progestins 2.
  • The risk of VTE with Drospirenone is compared to Levonorgestrel in several studies, with some showing a higher risk and others showing no increase in risk 2.
  • It is essential to consider the risks and benefits of a Drospirenone-containing COC in light of a woman's risk of a VTE before initiating use 2.

From the Research

Comparison of Ethynloestradiol/Levonorgestrel and Drospirenone for VTE Risk

  • The risk of venous thromboembolism (VTE) is higher for combined oral contraceptives (COCs) containing drospirenone compared to those containing levonorgestrel 3, 4, 5.
  • COCs with ethinyl-estradiol (EE) and levonorgestrel are associated with a lower VTE risk than those with EE and drospirenone 3, 4.
  • The VTE risk for transdermal COC, such as vaginal ring or patch, is as high as that for COC of 3rd or 4th generation, which includes those containing drospirenone 3.
  • Progestogen-only contraceptive methods, including oral levonorgestrel-only contraceptives, do not increase VTE risk significantly 3, 4, 6.

Recommendations for Contraception in Patients with VTE Risk

  • In patients with a history of VTE and/or a known thrombophilic defect, COCs are contraindicated, but progestagen-only contraceptives can be safely used 3, 4, 6.
  • Oral desogestrel- or levonorgestrel-only contraceptives, intrauterine device, and etonogestrel implants are recommended for women with a history of VTE and/or suffering from thrombophilia 4.
  • Screening for thrombophilia is not indicated in every woman with the wish for contraception, but should be restricted to certain cases, such as women with a positive history for VTE or with close relatives suffering from VTE in younger than 50 years 4.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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