From the Guidelines
Magnesium citrate dosing for constipation relief in adults is not explicitly stated in the provided evidence, but based on the available information, a dose of 500 mg/d to 1 g/d can be considered, although the bioavailability and clinical efficacy of magnesium citrate for chronic idiopathic constipation (CIC) are unknown. When considering magnesium supplementation for CIC, it is essential to note that magnesium oxide (MgO) has been evaluated in randomized controlled trials (RCTs) 1, but the efficacy of other formulations, such as magnesium citrate, is unknown. The available data on MgO suggest that it can exert a beneficial effect on constipation-related symptoms by creating an osmotic gradient in the GI tract, leading to net secretion of water and electrolytes 1. However, it is crucial to consider the potential risks, particularly in individuals with significant renal impairment, as hypermagnesemia is more likely to occur in these patients, and magnesium supplements should be avoided in those with a creatinine clearance of <20 mg/dL 1. Key points to consider when using magnesium citrate for constipation relief include:
- Drinking plenty of water to prevent dehydration
- Potential side effects, such as abdominal cramping, nausea, and electrolyte imbalances if overused
- Consulting a healthcare provider before use, especially for individuals with kidney disease, heart conditions, or those taking certain medications
- Using magnesium citrate occasionally rather than regularly to avoid dependence and electrolyte disturbances.