From the Research
It is generally safe to take creatine supplements while on Keppra (levetiracetam), but you should consult with your healthcare provider before combining them, as individual responses can vary and your specific medical history may affect this recommendation. When considering the use of creatine supplements with Keppra, it's essential to understand the potential effects of both. Creatine is a popular dietary supplement used to enhance athletic performance and muscle growth, while Keppra is an anticonvulsant medication used to treat epilepsy and seizures. According to the most recent and highest quality study available, 1, creatine supplementation is relatively well tolerated, especially at recommended dosages (i.e., 3-5 g/day or 0.1 g/kg of body mass/day), and there is no significant evidence to suggest that it causes kidney damage or renal dysfunction. However, another study 2 found that Levetiracetam (LEV) may cause increased creatine phosphokinase (CPK) concentration or rhabdomyolysis in some patients, highlighting the importance of monitoring serum CPK levels when treating patients with LEV. Some key points to consider when taking creatine supplements with Keppra include:
- Standard dosage: typically 3-5 grams daily
- Importance of staying well-hydrated
- Potential side effects: water retention, digestive discomfort, or muscle cramps
- Need for consultation with a healthcare provider to ensure safe use and minimize potential interactions or side effects It's also worth noting that the pharmacokinetics of levetiracetam, as described in 3, indicate that its clearance is renal in nature and directly dependent on creatinine clearance, which may be relevant when considering the use of creatine supplements. Overall, while the available evidence suggests that it is generally safe to take creatine supplements with Keppra, it's crucial to prioritize caution and consult with a healthcare provider to ensure safe and effective use.