What to do after vomiting caused by ingestion of polyethylene glycol (PEG)?

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Last updated: May 3, 2025View editorial policy

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From the Research

If you vomit after drinking polyethylene glycol (PEG), stop taking the solution temporarily and rest for 30-60 minutes to let your stomach settle, as this approach is supported by the most recent and highest quality study available 1.

Recommended Approach

When experiencing vomiting after consuming PEG, it is essential to prioritize hydration and manage symptoms effectively. The following steps can be taken:

  • Sip water or clear fluids slowly to stay hydrated.
  • When feeling better, try resuming the PEG solution at a slower pace, taking smaller amounts (about 8 ounces) every 15-20 minutes.
  • If vomiting persists, contact your healthcare provider as you may need an alternative preparation method.

Considerations for Management

  • Cooling the solution, drinking it through a straw, or adding a small amount of clear flavoring (like lemon juice) might make it more tolerable.
  • Vomiting can occur because PEG solutions expand in the digestive tract and can trigger the gag reflex when consumed too quickly.
  • If you were taking PEG for a scheduled procedure like a colonoscopy, inform your doctor about the vomiting as it may affect how well your bowel was cleaned, potentially requiring rescheduling or additional preparation.

Evidence-Based Support

The use of ondansetron, an anti-emetic medication, has been shown to be effective in managing vomiting in children with acute gastroenteritis 1. However, in the context of vomiting after PEG consumption, the primary focus should be on hydration and symptom management, rather than immediate use of anti-emetic medications.

Safety Precautions

It is crucial to be aware of the potential risks associated with PEG consumption, including the risk of accidental infusion into the lungs, which can lead to life-threatening respiratory failure 2. Therefore, careful monitoring and adherence to recommended administration guidelines are essential.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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