What is the diagnosis for a single lung whiteout, also known as unilateral pulmonary opacification (UPO)?

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Last updated: May 4, 2025View editorial policy

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Differential Diagnosis for Single Lung Whiteout

  • Single most likely diagnosis
    • Pneumonia: This is the most common cause of a single lung whiteout, as it can cause consolidation and opacification of the affected lung.
  • Other Likely diagnoses
    • Pulmonary edema: Unilateral pulmonary edema can occur due to various causes such as aspiration, infection, or trauma, leading to a whiteout appearance on imaging.
    • Lung contusion: Trauma to the chest can cause a lung contusion, resulting in hemorrhage and edema, which can appear as a whiteout on imaging.
    • Pleural effusion: A large pleural effusion can cause a whiteout appearance by obscuring the underlying lung tissue.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Pulmonary embolism: Although less common, a large pulmonary embolism can cause infarction and consolidation, leading to a whiteout appearance. Missing this diagnosis can be fatal.
    • Tension pneumothorax: A tension pneumothorax is a life-threatening condition that can cause a whiteout appearance due to the compression of the lung. Prompt recognition and treatment are crucial.
  • Rare diagnoses
    • Lipoid pneumonia: This rare condition occurs when lipids enter the lung tissue, causing inflammation and consolidation, which can appear as a whiteout on imaging.
    • Alveolar proteinosis: A rare disease characterized by the accumulation of protein and phospholipids in the alveoli, leading to a whiteout appearance on imaging.
    • Lymphoma: Uncommonly, lymphoma can cause a single lung whiteout due to infiltration of the lung tissue.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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