From the Research
The OATS results indicate significant metabolic imbalances, including fungal overgrowth, bacterial imbalances, mitochondrial dysfunction, and nutritional deficiencies, which require targeted supplementation and dietary modifications to address gut dysbiosis, support mitochondrial function, and improve detoxification pathways. The elevated arabinose and tricarballylic acid in the yeast and fungal markers section suggest possible fungal overgrowth, which is supported by the study on yeast mitochondria and its potential role in fungal pathogenesis 1. The high 4-hydroxyhippuric acid indicates bacterial imbalances, while elevated oxalic acid could contribute to kidney stone formation or other oxalate-related issues. The high succinic acid, 3-hydroxyglutaric acid, and 3-methylglutaconic acid point to mitochondrial dysfunction, potentially affecting energy production, as discussed in the study on mitochondrial structure and bioenergetics 2. Elevated neurotransmitter metabolites (homovanillic acid, DOPAC, and quinolinic acid) suggest dopamine and inflammatory pathway imbalances. Nutritional deficiencies are evident with low levels of vitamins B6, B5, and C, while high glutaric acid indicates possible riboflavin (B2) issues. Detoxification challenges are shown by high pyroglutamic acid and orotic acid.
Some key findings include:
- Elevated arabinose and tricarballylic acid, suggesting fungal overgrowth
- High 4-hydroxyhippuric acid, indicating bacterial imbalances
- Elevated oxalic acid, potentially contributing to kidney stone formation or other oxalate-related issues
- Mitochondrial dysfunction, as indicated by high succinic acid, 3-hydroxyglutaric acid, and 3-methylglutaconic acid
- Neurotransmitter metabolite imbalances, including elevated homovanillic acid, DOPAC, and quinolinic acid
- Nutritional deficiencies, including low levels of vitamins B6, B5, and C, and high glutaric acid
The study on yeast as probiotics suggests that certain yeast strains, such as Saccharomyces boulardii, may have potential therapeutic benefits in addressing gut dysbiosis and improving overall health 3. However, the most recent and highest quality study on mitochondrial dysfunction and its relationship to fungal pathogenesis 1 suggests that addressing mitochondrial function may be a critical component of treatment. Therefore, a comprehensive treatment plan should include targeted supplementation and dietary modifications to address gut dysbiosis, support mitochondrial function, and improve detoxification pathways.