What is the dose of intravenous (IV) Venofer (iron sucrose)?

From the Guidelines

The recommended dose of IV Venofer is 200 mg as a maximum single dose, with a maximum weekly dose of 500 mg, and should be administered over at least 30 minutes for the maximum dose, as per the European Medicines Agency (EMA) guidelines 1. When administering IV Venofer, it is essential to consider the patient's individual needs and medical history. The dose may vary depending on the patient's condition, such as chronic kidney disease (CKD) or iron deficiency anemia.

• Key considerations for IV Venofer administration include:
  • Concentration of elemental iron: 20 mg/ml
  • Maximum single dose: 200 mg
  • Maximum weekly dose: 500 mg
  • Minimum infusion time for maximum dose: 30 minutes (EMA) or 15 minutes (FDA) The patient's response to treatment, including hemoglobin levels and iron stores, should be closely monitored to adjust the dosing regimen as needed. It is crucial to follow the recommended guidelines and consult with a healthcare professional to determine the best course of treatment for each individual patient, as stated in the study published in Kidney International 1.

From the FDA Drug Label

2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. The dosage of Venofer is expressed in mg of elemental iron. Each mL contains 20 mg of elemental iron.

1. 1 Mode of Administration Administer Venofer only intravenously by slow injection or by infusion. The dosage of Venofer is expressed in mg of elemental iron. Each mL contains 20 mg of elemental iron.
2. 2 Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD) Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session
3. 3 Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0. 9% NaCl over a period of 15 minutes.

The dose of IV Venofer is:

• 100 mg for adult patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD) administered as a slow intravenous injection or infusion.
• 200 mg for adult patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) administered as a slow intravenous injection or infusion. 2

From the Research

Dose of IV Venofer

• The dose of IV Venofer (iron sucrose) can vary depending on the patient's condition and the specific treatment regimen 3.
• In one study, patients with chronic kidney disease (CKD) received an IV dose of iron sucrose 500 mg infused over three hours on two consecutive days 3.
• Another study used a single dose of 200 mg of iron sucrose in hemodialysis (HD) patients and up to 1000 mg in non-dialysis-dependent (NDD) CKD patients 4.
• Ferric carboxymaltose (FCM) is another intravenous iron formulation that can be given in higher single doses, with a maximum dose of 1000 mg in NDD-CKD patients 4.
• The dose of ferric derisomaltose (FDI) is typically 1000 mg as a single infusion 5.

Administration and Safety

• IV iron formulations can be administered undiluted or diluted in saline solution, and the infusion rate can vary depending on the specific product and patient condition 4, 3, 6.
• The safety of IV iron formulations has been evaluated in several studies, with most reporting a low rate of adverse events and no significant differences between treatment groups 4, 3, 6, 5.
• However, one study found that iron sucrose (IS) infusion was associated with a significant decrease in endothelial function, whereas ferric carboxymaltose (FCM) did not have this effect 6.