From the Research
Fluvoxamine may be used off-label to treat certain symptoms associated with autism spectrum disorder (ASD), such as repetitive behaviors, anxiety, or obsessive-compulsive symptoms, as evidenced by a study published in 1996 1.
Introduction to Fluvoxamine
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) primarily approved for treating obsessive-compulsive disorder (OCD) and depression.
Use in Autism
In the context of autism, fluvoxamine might be prescribed to address symptoms that commonly co-occur with ASD.
- When prescribed for these symptoms in autism, dosing typically starts low (25-50mg daily for adults, lower for children) and may be gradually increased based on response and tolerability.
- Treatment duration varies depending on symptom improvement and side effects.
Mechanism and Side Effects
Fluvoxamine works by increasing serotonin levels in the brain, which may help regulate behaviors and mood.
- Common side effects include nausea, headache, insomnia, and agitation, particularly when starting treatment.
Comprehensive Treatment Approach
It's essential to note that medication should be part of a comprehensive treatment approach for autism that includes behavioral therapies and educational interventions, as no medication treats the core features of autism itself.
Evidence Base
The use of fluvoxamine in autism is supported by a double-blind, placebo-controlled study published in 1996, which found that fluvoxamine was superior to placebo in reducing repetitive thoughts and behavior, maladaptive behavior, and aggression, and in improving some aspects of social relatedness in adults with autistic disorder 1. However, more recent and higher-quality studies are needed to fully understand the efficacy and safety of fluvoxamine in treating autism symptoms.
Current Recommendations
Based on the available evidence, fluvoxamine may be considered as an off-label treatment option for certain symptoms associated with autism, but its use should be carefully monitored and individualized, taking into account the potential benefits and risks, as well as the need for comprehensive behavioral and educational interventions 1.