From the Research
A deletion of chromosome 17 in an embryo detected during IVF will not resolve or correct itself, and the chances of it resolving are essentially zero. Chromosomal deletions are permanent genetic changes that occur during the formation of eggs or sperm, or shortly after fertilization. Once a deletion is present in the embryonic cells, it will remain in all cells as the embryo develops. This is because chromosomal material that has been deleted cannot be spontaneously restored through natural biological processes 1. The severity of the condition resulting from a chromosome 17 deletion depends on the size and specific location of the missing genetic material, as chromosome 17 contains many important genes related to development.
Some key points to consider:
- Chromosomal deletions are permanent and will not resolve on their own
- The severity of the condition depends on the size and location of the deletion
- Chromosome 17 contains many important genes related to development
- Preimplantation genetic testing (PGT) can identify chromosomal abnormalities, including deletions, in embryos created through IVF 1
- Genetic counseling is recommended to understand the potential implications of a chromosome 17 deletion and to discuss options for affected embryos
The most recent and highest quality study on this topic is from 2020, which discusses the importance of preimplantation genetic testing for chromosomal abnormalities, including deletions 1. This study highlights the value of identifying chromosomal abnormalities in embryos before transfer, in order to improve clinical outcomes and reduce the risk of miscarriage and congenital disorders.
In terms of the chances of a deletion of chromosome 17 resolving, the evidence suggests that this is highly unlikely. Chromosomal deletions are stable and will not spontaneously resolve, and the focus should be on identifying and managing the potential consequences of the deletion, rather than hoping for a resolution 1.