Is there a relationship between intravenous (IV) iron therapy and the development or exacerbation of rosacea?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 6, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Intravenous (IV) iron therapy is generally not known to directly cause or worsen rosacea, though individual reactions can vary. If you have rosacea and need IV iron for iron deficiency anemia, you can typically proceed with treatment while monitoring your skin condition. Common IV iron preparations include iron sucrose (Venofer), ferric carboxymaltose (Injectafer), and iron dextran, administered in hospital settings under medical supervision 1. During treatment, maintain your regular rosacea management routine, which might include topical metronidazole, azelaic acid, or oral medications like doxycycline, as recommended by recent reviews on rosacea management 2, 3.

Some key points to consider when managing rosacea include:

  • Avoiding trigger factors and proper skin care
  • Using topical medications as one of the first-line choices for patients with erythematous and mild to severe papulopustular rosacea 4
  • Considering combination therapy for mixed forms of characteristic rosacea symptoms
  • Monitoring for potential skin flare-ups after iron infusion and informing your healthcare provider if any occur

It's essential to note that the connection between iron and rosacea is not well-established scientifically, though iron is involved in inflammatory processes throughout the body 2. Most patients with both conditions can successfully manage them simultaneously without significant interaction between treatments. However, individual reactions can vary, and rare cases of flushing or skin reactions may occur after iron infusion 1.

References

Research

Rosacea management: A comprehensive review.

Journal of cosmetic dermatology, 2022

Research

Rosacea Treatment: Review and Update.

Dermatology and therapy, 2021

Research

Rosacea Management: Update on general measures and topical treatment options.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.