Is there an association between creatine (creatine monohydrate) supplementation and alopecia (hair loss)?

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From the Guidelines

There is no conclusive evidence to suggest that creatine supplementation directly causes hair loss, and individuals can safely use creatine without significant concern for hair loss as a side effect. While some studies have raised concerns about the potential for creatine to increase dihydrotestosterone (DHT) levels, which is associated with male pattern baldness, the current evidence is limited and inconclusive 1. The study by Leonberg-Yoo et al, published in 2020, discusses the potential nephrotoxicity of various dietary supplements, including creatine monohydrate, but does not provide any evidence linking creatine to hair loss 1. In fact, the study highlights the importance of considering the potential effects of dietary supplements on kidney function, particularly in individuals with pre-existing kidney disease, but does not mention hair loss as a potential side effect of creatine supplementation.

Some key points to consider when evaluating the relationship between creatine and hair loss include:

  • The lack of strong scientific evidence supporting a direct link between creatine supplementation and hair loss
  • The potential for creatine to increase DHT levels, which may contribute to male pattern baldness, but this finding has not been consistently replicated in larger studies
  • The importance of considering individual factors, such as genetics, age, and hormonal changes, which can influence hair loss
  • The need for further research to fully understand the potential effects of creatine supplementation on hair loss

It is essential to note that the study by Leonberg-Yoo et al 1 provides valuable insights into the potential effects of dietary supplements on kidney function, but does not provide any conclusive evidence on the relationship between creatine and hair loss. Therefore, individuals can safely use creatine supplementation without significant concern for hair loss as a side effect, but should always consult with a healthcare provider if they have concerns about potential side effects or interactions with other medications.

From the Research

Creatine and Hair Loss

  • There is no direct evidence that creatine causes hair loss, as shown in a 12-week randomized controlled trial 2.
  • The study found no significant differences in dihydrotestosterone (DHT) levels, DHT-to-testosterone ratio, or hair growth parameters between the creatine and placebo groups 2.
  • The results of this study provide strong evidence against the claim that creatine contributes to hair loss 2.

Alternative Supplements for Hair Loss

  • Saw palmetto, a botanical extract with antiandrogenic properties, has been shown to have positive effects on hair regrowth in patients with androgenetic alopecia (AGA) and telogen effluvium 3.
  • A nutritional supplement containing omega 3&6 and antioxidants has been found to improve hair density and reduce telogen hair percentage in women with female pattern hair loss 4.
  • Biotin, a popular hair supplement, has limited research to support its efficacy in healthy individuals, and its utility as a hair supplement is not supported by high-quality studies 5, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Does creatine cause hair loss? A 12-week randomized controlled trial.

Journal of the International Society of Sports Nutrition, 2025

Research

Effect of a nutritional supplement on hair loss in women.

Journal of cosmetic dermatology, 2015

Research

Biotin for Hair Loss: Teasing Out the Evidence.

The Journal of clinical and aesthetic dermatology, 2024

Research

A Review of the Use of Biotin for Hair Loss.

Skin appendage disorders, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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