What are the risks associated with ingesting 5-Hour Energy (energy supplement) drinks?

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Last updated: May 6, 2025View editorial policy

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From the Guidelines

I strongly advise against consuming 5-hour Energy drinks due to the potential health risks associated with their high caffeine content and other stimulants, as highlighted in a 2020 study published in Advances in Nutrition 1. The importance of avoiding these energy drinks cannot be overstated, particularly among adolescents and young adults who are the primary consumers of these products. Some key points to consider include:

  • The high levels of caffeine in 5-hour Energy drinks, approximately 200mg per bottle, can cause serious side effects such as increased heart rate, elevated blood pressure, anxiety, insomnia, and digestive problems.
  • Regular consumption of these energy drinks can lead to dependency and withdrawal symptoms when stopped, as well as potentially dangerous interactions with alcohol or medications.
  • The American Academy of Pediatrics (AAP) has stated that "stimulant-containing energy drinks have no place in the diets of children and adolescents" 1, emphasizing the need for caution and responsible consumption habits.
  • Instead of relying on energy drinks for a quick energy boost, it is recommended to focus on getting adequate sleep, staying hydrated, eating balanced meals, and exercising regularly to maintain overall health and well-being.
  • If you are consistently feeling fatigued, it is essential to consult with your healthcare provider to identify and address the underlying cause rather than masking symptoms with energy drinks.

From the Research

Importance of Not Ingesting 5 Hour Energy Drinks

The consumption of energy drinks, such as 5 Hour Energy, has been linked to several adverse health effects, particularly in the cardiovascular system. Some of the key reasons to avoid ingesting these drinks include:

  • Cardiac arrhythmias, myocardial infarction, and sudden cardiac death 2, 3
  • Increased heart rate, blood pressure, and contractility of the heart 3
  • Prolonged QT interval, aortic dissection, and death 2
  • Insomnia, stress, and depressive mood in the pediatric population 4
  • Insomnia, jitteriness/restlessness/shaking hands, and gastrointestinal upset in the adult population 4

Risks Associated with Energy Drink Consumption

Energy drinks contain high levels of caffeine, taurine, sugars, and B-vitamins, which can contribute to the adverse health effects associated with their consumption. The risks associated with energy drink consumption include:

  • Cardiovascular disease, including atrial and ventricular arrhythmias, myocardial infarctions, and cardiomyopathies 3
  • Increased odds of insomnia and jitteriness/activeness compared to the control group 4
  • Reduced likelihood of sedation effects but increased likelihood of stimulatory effects when consumed with alcohol 4

Safe Caffeine Intake

While moderate caffeine intake is not associated with increased risks of total cardiovascular disease, the point at which caffeine intake may cause harm to the cardiovascular system is not readily identifiable 5. However, it is recommended that individuals avoid frequent energy drink consumption (5-7 energy drinks/week) and avoid co-consumption with alcohol 4. Additionally, there is a need for age regulations, transparency of ingredients, clear labeling of adverse effects, and education of consumers regarding the risks associated with energy drink consumption 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Energy drink consumption: a rising public health issue.

Reviews in cardiovascular medicine, 2022

Research

Caffeine and cardiovascular health.

Regulatory toxicology and pharmacology : RTP, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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