What is the brand name for Cefpodoxime (Cefpodoxime proxetil)?

From the Guidelines

Cefpodoxime is available under several brand names, with Vantin being the most common in the United States, as well as Banan in Japan and Orelox in various European countries.

Key Points

• Cefpodoxime is a third-generation cephalosporin antibiotic that comes in oral form, typically as cefpodoxime proxetil, which is a prodrug that converts to the active form in the body 1.
• It's commonly prescribed at doses of 100-400 mg twice daily, depending on the infection being treated, with typical treatment durations of 5-14 days.
• The medication works by inhibiting bacterial cell wall synthesis, making it effective against many gram-positive and gram-negative bacteria.
• Patients should take cefpodoxime with food to enhance absorption and should complete the full course of treatment even if symptoms improve before finishing the prescription.
• Those with penicillin allergies should inform their healthcare provider before taking cefpodoxime, as there is potential for cross-reactivity between cephalosporins and penicillins.

Important Considerations

• Cefpodoxime proxetil has been ranked as having a predicted clinical efficacy of 83% to 88% for adults with acute bacterial rhinosinusitis, according to the study published in Otolaryngology--head and neck surgery 1.
• The study also recommends cefpodoxime proxetil as an initial therapy option for adult patients with mild disease who have not received antibiotics in the previous 4 to 6 weeks 1.

From the FDA Drug Label

Cefpodoxime proxetil tablets, USP contain cefpodoxime proxetil equivalent to 100 mg or 200 mg of cefpodoxime activity Cefpodoxime Proxetil Tablets, USP 200 mg* Rx only 100 Tablets SANDOZ

The brand name for cefpodoxime is not explicitly stated in the provided drug labels, but Sandoz is mentioned as the manufacturer of Cefpodoxime Proxetil Tablets, USP 2. However, it is unclear if Sandoz is the brand name or just the manufacturer.

• Key points:
  • Cefpodoxime is the active metabolite of cefpodoxime proxetil 2
  • Sandoz is the manufacturer of Cefpodoxime Proxetil Tablets, USP 2

From the Research

Cefpodoxime Brand Name

• The studies provided do not mention a specific brand name for cefpodoxime 3, 4, 5, 6.
• However, it is mentioned that cefpodoxime is available as a prodrug called cefpodoxime proxetil, which is absorbed readily from the gut 3.
• Cefpodoxime proxetil is an oral third-generation cephalosporin with a broad spectrum of antibacterial activity 4.

Uses of Cefpodoxime

• Cefpodoxime is used to treat various bacterial infections, including upper and lower respiratory tract infections, sinusitis, otitis media, skin and soft tissue infections, and urinary tract infections 3, 4, 5.
• It is also used as an alternative to levofloxacin for antibiotic prophylaxis in allogeneic stem cell transplant patients 6.

Efficacy of Cefpodoxime

• Cefpodoxime has been shown to be effective in treating various bacterial infections, with clinical efficacy rates similar to those of other antibiotics such as amoxicillin/clavulanic acid, cefixime, and cefuroxime axetil 4, 5.
• It has also been shown to be effective in preventing antibiotic prophylaxis failure in allogeneic stem cell transplant patients, with similar rates of neutropenic fever and antibiotic prophylaxis failure compared to levofloxacin 6.