From the Research
PRP can potentially cause delayed hypersensitivity reactions, though these are relatively uncommon, as reported in a case study from 2019 1. PRP is derived from a patient's own blood, which theoretically reduces the risk of allergic reactions compared to foreign substances. However, delayed hypersensitivity reactions can still occur due to the processing agents used during PRP preparation, such as anticoagulants, or from the high concentration of growth factors and cytokines in the preparation. These reactions typically manifest 24-72 hours after administration and may present as inflammation, redness, swelling, or pain at the injection site. The mechanism involves T-cell mediated immune responses rather than immediate IgE-mediated allergic reactions. Some key points to consider include:
- Patients with a history of multiple allergies or autoimmune conditions may be at higher risk for such reactions.
- If a delayed hypersensitivity reaction is suspected, treatment typically involves anti-inflammatory medications and, in some cases, corticosteroids.
- Healthcare providers should monitor patients after PRP administration and inform them about the possibility of delayed reactions, even though the autologous nature of PRP makes severe reactions uncommon, as noted in a review of adverse events related to PRP therapy from 2024 2. It's also worth noting that while PRP has been used in various medical fields, including orthopedic procedures, cardiac surgery, and sports injuries, the safety profile of PRP treatment remains unclear, and more research is needed to fully understand its risks and benefits, as discussed in a review of evidence-based indications of PRP therapy from 2021 3.