Differential Diagnosis for Upper Lip Angioedema + Hypertension
- Single Most Likely Diagnosis
- Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema: This is a common side effect of ACE inhibitors, which are often used to treat hypertension. The mechanism involves the accumulation of bradykinin, leading to increased vascular permeability and angioedema.
- Other Likely Diagnoses
- Allergic Reaction: An allergic reaction to a food, medication, or other substance could cause angioedema, and hypertension could be a comorbidity or a consequence of the allergic response.
- Hereditary Angioedema (HAE): Although less common, HAE could present with recurrent episodes of angioedema, including upper lip involvement, and hypertension might be a coincidental finding.
- Do Not Miss Diagnoses
- Anaphylaxis: Although angioedema is a key feature, anaphylaxis is a life-threatening condition that requires immediate recognition and treatment. Hypertension might not be a primary feature, but it could be present due to the body's stress response.
- Superior Vena Cava Syndrome: This condition, often caused by a thrombosis or external compression, can lead to facial edema, including the upper lip, and hypertension due to increased venous pressure.
- Rare Diagnoses
- Acquired Angioedema: This condition is associated with lymphoproliferative disorders, autoimmune diseases, or the use of certain medications, and it could present with upper lip angioedema and hypertension as part of a broader clinical picture.
- Erythema Multiforme: A skin condition characterized by target lesions, which can sometimes involve the lips and be accompanied by angioedema, although hypertension is not a direct association.