From the Guidelines
Wellbutrin (bupropion) is a viable option for treating low libido, as suggested by the latest guidelines from the National Comprehensive Cancer Network 1. When considering treatment for low libido, it's essential to evaluate the patient's overall health and medical history. According to the nccn guidelines® insights: survivorship, version 2.2024 1, available treatment options for low libido include discussion of available drugs such as bupropion.
- Typical dosing of Wellbutrin for low libido ranges from 150-300mg daily, usually starting at 150mg and potentially increasing after several weeks if needed.
- The mechanism of action of Wellbutrin, affecting dopamine and norepinephrine rather than serotonin, may contribute to its more favorable sexual side effect profile compared to other antidepressants.
- Potential side effects of Wellbutrin include insomnia, dry mouth, headache, and increased anxiety, and it is contraindicated for people with seizure disorders, eating disorders, or those abruptly discontinuing alcohol or sedatives.
- It is crucial to discuss this option with a doctor, as they will need to evaluate the patient's complete medical history, current medications, and specific situation before determining if Wellbutrin is appropriate for their low libido concerns, as recommended by the nccn guidelines® insights: survivorship, version 2.2024 1.
From the Research
Wellbutrin for Low Libido
- Wellbutrin, also known as bupropion, is an antidepressant that has been studied for its potential to treat low libido in women 2, 3.
- Research suggests that bupropion may be effective in enhancing sexual function in certain individuals, particularly those with depression-related sexual dysfunction 2.
- A study published in 2001 found that bupropion sustained release (SR) may be a treatment option for women with hypoactive sexual desire disorder (HSDD), with 29% of participants responding to treatment 3.
- However, it is essential to note that low libido is a complex problem with multiple causes, and treatment options should be individualized based on the biopsychosocial components of desire that are compromised in a woman 4, 5, 6.
- Currently, there are no Food and Drug Administration-approved pharmacologic treatments for low sexual desire, but bupropion may be considered as an alternative treatment option for depression that does not include the sexual side effects associated with most antidepressants 2, 6.