From the Guidelines
Night sweats can be effectively managed through lifestyle modifications and cognitive behavioral therapy (CBT), as evidenced by recent studies 1. To alleviate night sweats, several approaches can be considered, depending on the underlying cause.
- For immediate relief, keeping the bedroom cool, using moisture-wicking bedding and sleepwear, and maintaining a healthy weight can help minimize vasomotor symptoms, including night sweats 1.
- Lifestyle modifications such as weight loss, quitting smoking, and limiting alcohol intake can also help alleviate hot flashes and night sweats in breast cancer survivors 1.
- CBT has been shown to reduce vasomotor symptoms, including night sweats, in the general population and in cancer and survivor populations 1.
- Non-hormonal medications like venlafaxine, paroxetine, or gabapentin may also be effective in reducing menopausal night sweats, as suggested by earlier studies 1. However, the most recent and highest quality study 1 prioritizes lifestyle modifications and CBT as the primary approaches for managing night sweats, emphasizing the importance of addressing the root cause of the symptoms.
- Identifying and addressing the underlying cause of night sweats is crucial for effective treatment, and consulting a healthcare provider for proper diagnosis is essential if night sweats persist or are accompanied by other concerning symptoms.
From the Research
Night Sweats Treatment Options
- Hormone replacement therapy (HRT) is considered the most effective treatment for managing menopausal hot flushes and night sweats 2
- Alpha adrenergic blockers may reduce night sweats in patients taking serotonin reuptake inhibitors 3
- Thalidomide and thioridazine may benefit some terminal cancer patients with night sweats 3
- Progesterone is effective for hot flushes and night sweats (vasomotor symptoms, VMS), improves sleep and is likely safe in menopausal women 4
Diagnostic Evaluation
- A thorough history, physical examination, and directed laboratory and radiographic studies can help exclude serious causes of night sweats 5, 6
- Laboratory tests such as complete blood count, tuberculosis testing, thyroid-stimulating hormone levels, HIV testing, and C-reactive protein level can be used to evaluate night sweats 6
- Imaging studies such as chest radiography, computed tomography of the chest and/or abdomen, and bone marrow biopsy may be considered selectively 6
Treatment Approaches
- Algorithmic approaches to evaluation are not evidence-based, and treatment should be based on the underlying cause of night sweats 3
- If a clinical diagnosis is apparent, specific treatment for four to eight weeks may be offered 6
- Reassurance and continued monitoring are recommended if laboratory and imaging results are normal and no additional disorders are suspected 6