What is the differential diagnosis for a 15-year-old patient presenting with upper respiratory infection (URI) symptoms, fever, and pain in the ribs and calf?

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Differential Diagnosis for a 15-year-old with URI symptoms, fever, sore ribs, and calf

  • Single most likely diagnosis:
    • Influenza: This is a common cause of URI symptoms, fever, and myalgias (muscle pains), which could explain the sore ribs and calf. The presentation is consistent with a viral infection, and influenza is prevalent in the community during certain times of the year.
  • Other Likely diagnoses:
    • Viral pneumonia: Could present with similar symptoms, including fever, URI symptoms, and chest pain (sore ribs) due to coughing or pleuritic pain.
    • Mononucleosis (Mono): Caused by Epstein-Barr virus, it can present with fever, sore throat, fatigue, and myalgias. Although less common, it's a consideration in adolescents.
    • Mycoplasma pneumonia: A type of atypical pneumonia that can cause symptoms similar to viral pneumonia, including fever, cough, and chest pain.
  • Do Not Miss diagnoses:
    • Pulmonary embolism: Although rare in adolescents, it's a life-threatening condition that could cause chest pain and shortness of breath. Risk factors such as recent travel, immobility, or family history of clotting disorders would increase suspicion.
    • Bacterial pneumonia: Can present similarly to viral pneumonia but requires prompt antibiotic treatment. Certain bacteria like Streptococcus pneumoniae can cause severe disease.
    • Sepsis: A life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. Fever, tachycardia, and signs of organ dysfunction would be red flags.
  • Rare diagnoses:
    • Leptospirosis: A bacterial infection that can cause fever, headache, and muscle aches, including calf pain. It's more common in individuals exposed to contaminated water or soil.
    • Lyme disease: Caused by Borrelia burgdorferi, transmitted by tick bites. It can cause fever, headache, fatigue, and muscle pains, but the presence of a rash (erythema migrans) is often a distinguishing feature.
    • Osteomyelitis: An infection of the bone that could cause localized pain, fever, and swelling. It's less common but should be considered if there's a history of trauma or if the pain is localized to a specific area.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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