From the FDA Drug Label
Indications and Usage For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
- Urea (TOP) is useful for the treatment of keratosis pilaris 1.
- The treatment involves the use of urea for debridement and promotion of normal healing of hyperkeratotic surface lesions.
- Key benefits of using urea for keratosis pilaris include the treatment of hyperkeratotic conditions and promotion of normal healing.
From the Research
Keratosis pilaris can be effectively treated with a combination of gentle exfoliation and moisturizing, with topical lactic acid being the most commonly used first-line therapy, as reported by 43.63% of survey respondents 2. To start treatment, use a mild chemical exfoliant containing alpha hydroxy acids (like glycolic acid or lactic acid) or beta hydroxy acids (like salicylic acid) at concentrations of 2-10%, applied once daily to affected areas. Products such as AmLactin lotion (12% lactic acid), CeraVe SA Cream (with salicylic acid), or Glytone KP Kit are effective options. After exfoliating, apply a thick, fragrance-free moisturizer containing urea or ceramides to hydrate the skin, such as a 20% urea cream, which has been shown to be well-tolerated and effective in improving skin smoothness and texture 3. Use gentle, non-soap cleansers when bathing, and avoid hot water which can worsen dryness. This regimen should be followed consistently for at least 4-6 weeks to see improvement. These treatments work by removing excess keratin buildup that causes the characteristic bumps and by improving skin hydration to prevent further plugging of hair follicles. For severe cases that don't respond to over-the-counter treatments, prescription retinoids like tretinoin or adapalene may be recommended by a dermatologist 4. Some key points to consider when treating keratosis pilaris include:
- Avoiding long baths or showers, and using mild soaps or cleansers 4
- Using topical keratolytic agents, followed by topical retinoids and corticosteroids if necessary 4
- Considering laser therapy or microdermabrasion for refractory cases 4
- Being aware that keratosis pilaris often improves with age and may flare during dry winter months, so consistent treatment is key 5.