From the Research
The minimum effective dose of NAD for daily injection cannot be definitively established due to the lack of standardized dosing protocols and FDA approval for specific medical conditions. However, doses used in clinical settings typically range from 100mg to 1000mg per day, with many practitioners starting at lower doses (around 200-250mg) and adjusting based on individual response 1. It is essential to note that NAD injections should only be administered under medical supervision due to potential side effects, including flushing, headache, chest tightness, and injection site reactions. The rationale behind NAD supplementation is to increase cellular levels of this coenzyme, which plays crucial roles in energy metabolism, DNA repair, and cellular signaling pathways. Age-related decline in NAD levels has been associated with various health conditions, which is why supplementation has gained interest. Before considering NAD injections, patients should undergo proper medical evaluation, discuss their health goals and medical history with a healthcare provider, and consider that oral NAD precursors like nicotinamide riboside or nicotinamide mononucleotide might be safer alternatives for many individuals. Some studies have raised concerns about the potential risks of NAD+ boosting, such as increased atherosclerotic plaques and inflammation in certain populations 2. Therefore, it is crucial to approach NAD supplementation with caution and prioritize individualized medical guidance. Key considerations for NAD supplementation include:
- Starting with low doses and adjusting based on individual response
- Monitoring for potential side effects
- Considering oral NAD precursors as alternative options
- Prioritizing medical supervision and guidance throughout the supplementation process.