What is the NAD (Nicotinamide Adenine Dinucleotide) injection schedule?

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From the Research

NAD+ injections should be administered with caution, considering the potential risks and benefits, and the schedule should be individualized based on personal health goals, age, and existing health conditions, with a typical initial intensive phase of 1-2 treatments per week for 4-6 weeks, followed by maintenance doses of 1-2 injections per month, as supported by the most recent study 1. The standard dosage ranges from 100-500mg per injection, with most clinics starting at lower doses and adjusting based on individual response.

  • The timing between injections allows NAD+ levels to build up in the body while giving time for any potential side effects like flushing or mild discomfort to subside.
  • NAD+ is a coenzyme involved in cellular energy production and DNA repair, and supplementation aims to counteract the natural decline that occurs with aging.
  • Individual responses vary, so the schedule may need adjustment based on personal health goals, age, and existing health conditions.
  • Always consult with a healthcare provider before starting NAD+ therapy to determine the most appropriate schedule for your specific needs, as recent studies have highlighted the importance of careful consideration of NAD+ supplementation, particularly in certain populations, such as those with atherosclerosis, where high-dose NAD+ supplementation may increase aortic plaque lesions and systemic inflammation 2.
  • The metabolism of NAD+ precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), involves enterohepatic circulation, where they are converted to nicotinic acid (NA) and then used in the liver to synthesize NAD+ 1.
  • The safety and effectiveness of NAD+ supplementation have been evaluated in various clinical conditions, including chronic fatigue syndrome, older adults, Parkinson's disease, overweight, postmenopausal prediabetes, and Alzheimer's disease, with overall positive results, but also highlighting the need for further research to determine the optimal dosage and schedule for specific diseases 3.

References

3
Research

Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.

American journal of physiology. Endocrinology and metabolism, 2024

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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