From the Research
Sermorelin is a synthetic peptide that stimulates the release of growth hormone from the pituitary gland, typically prescribed to treat growth hormone deficiency in children and adults, and is sometimes used off-label for anti-aging purposes. It works by mimicking the action of growth hormone-releasing hormone (GHRH), a natural hormone in the body 1. The standard dosage ranges from 100 to 500 mcg administered via subcutaneous injection, usually given once daily before bedtime when natural growth hormone secretion is highest.
Key Points
- Sermorelin stimulates the release of growth hormone from the pituitary gland, mimicking the action of GHRH 1.
- It is typically prescribed to treat growth hormone deficiency in children and adults, and is sometimes used off-label for anti-aging purposes.
- The standard dosage ranges from 100 to 500 mcg administered via subcutaneous injection, usually given once daily before bedtime when natural growth hormone secretion is highest.
- Treatment duration varies based on the condition being treated, with some patients requiring ongoing therapy.
- Side effects may include injection site reactions, headache, flushing, dizziness, and rarely, allergic reactions.
Recent Study Findings
A recent study published in 2017 found that sermorelin therapy increases serum insulin-like growth factor 1 (IGF-1) levels, with strict compliance to thrice-daily dosing 2. Another study published in 1996 found that once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy 3.
Important Considerations
Unlike synthetic growth hormone, sermorelin only stimulates the body's natural production of growth hormone when needed, potentially reducing risks of overdosing. It's essential to note that sermorelin requires a prescription and should only be used under medical supervision, as improper use can lead to adverse effects.