Does phototoxicity cause progressive visual impairment?

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Last updated: May 8, 2025View editorial policy

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From the Guidelines

Eye damage from light can indeed cause gradual blindness that progresses over time, particularly in conditions like central serous chorioretinopathy (CSC), where prolonged exposure to light may exacerbate the disease, leading to a decline in best-corrected visual acuity (BCVA) and contrast sensitivity due to damage to macular photoreceptors 1.

Key Points to Consider

  • The progression of vision loss in CSC is often gradual, with patients experiencing a decline in BCVA and contrast sensitivity over time, which can be due to changes in foveal atrophic RPE, photoreceptor damage, posterior cystoid retinal degeneration (PCRD), and/or secondary microvascular proliferation (MNV) 1.
  • Up to 13% of eyes with chronic CSC (cCSC) can lead to legal blindness, with BCVA reaching 20/200 or worse after 10 years, highlighting the importance of early intervention and management 1.
  • The disease course can be slowed, and BCVA stabilized or even improved with photodynamic therapy (PDT) treatment, emphasizing the need for timely and appropriate treatment 1.

Important Considerations for Patients

  • Patients with cCSC often experience a decrease in vision-related quality of life, which is correlated with disease duration, making it essential to address the condition promptly and effectively 1.
  • Bilateral disease activity and severe cCSC phenotypes are associated with a higher risk of developing severe, irreversible visual impairment, underscoring the importance of close monitoring and aggressive management in these cases 1.
  • Prevention and protective measures, such as wearing UV-blocking sunglasses and using proper eye protection during activities with bright light exposure, are crucial in reducing the risk of eye damage from light and slowing the progression of vision loss.

From the Research

Eye Damage from Light

  • The effects of light on the eye are being increasingly recognized, with both acute and chronic light damage posing risks to eye health 2.
  • Chronic light exposure has been associated with ocular diseases such as cataracts, age-related macular degeneration, pterygium, and climatic droplet keratopathy 2.

Gradual Blindness

  • There is evidence to suggest that chronic sunlight exposure contributes to ocular disease, which can potentially lead to gradual blindness over time 2.
  • However, the exact relationship between eye damage from light and gradual blindness is not fully understood and requires further research.

Phototherapy and Eye Damage

  • Phototherapy, which involves exposure to specific wavelengths of light, can be used to treat various skin conditions, but it also carries a risk of eye damage 3.
  • The use of phototherapy has been shown to cause photodamage, xerosis, erythema, actinic keratosis, sunburn, and tenderness, among other adverse effects 3.
  • It is essential to take precautions to protect the eyes during phototherapy, especially in children and individuals with pre-existing eye conditions 3.

Prevention and Management

  • Preventive measures, such as informing patients of the possibility of increased sun sensitivity and the use of sun protective measures, can help mitigate the risks associated with eye damage from light 2, 4.
  • In cases where eye damage has occurred, treatment with topical corticosteroids or other medications may be necessary to manage symptoms and prevent further damage 5, 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Light damage to the eye.

The Journal of the Florida Medical Association, 1994

Research

Management of atopic dermatitis: safety and efficacy of phototherapy.

Clinical, cosmetic and investigational dermatology, 2015

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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