From the Research
Nystatin cream should be used for 1-2 weeks to treat fungal skin infections like candidiasis, as evidenced by a recent review of topical and systemic treatments for cutaneous candidiasis 1. The treatment duration may vary depending on the severity of the infection and the patient's response to treatment.
- For mild cases, applying the cream 2-3 times daily until symptoms resolve, then continuing for an additional 1-2 days to prevent recurrence, may be sufficient.
- For diaper rash, applying the cream with each diaper change may be necessary.
- For intertrigo or other skin fold infections, treatment may extend to 2-4 weeks. It is essential to keep the affected area clean and dry during treatment to enhance effectiveness. If symptoms persist beyond 2 weeks, consulting a healthcare provider is recommended, as this may indicate resistance or misdiagnosis. Nystatin works by binding to ergosterol in the fungal cell membrane, creating pores that lead to cell death, and is effective specifically against Candida species, with minimal systemic absorption when applied topically, making it safe for most patients, including infants and pregnant women 1.